Projets en cours
Analyses biologiques
- Do parameters of ferroptotic programmed cell death can predict the progression of the ALS/ PIs: Devos/ Rolland/Garçon (Lille)
- Combination of serum and CSF neurofilament light and neuroinflammatory biomarkers to evaluate ALS/ PIs: Verschueren/ Boucraut (Marseille)
- ALS-ISO-Marker/ PIs: Vigor/ Durand/Devos/Rolland/ Garçon (Montpellier, Lille)
- Measure of the amount of soluble TNFα receptor (sTNFR) in the CSF of ALS patients as biomarker of the dysfunction of PrPC/PDK1/ADAM10-17 signaling pathway in motor neurons/ PIs Shneider, Launay, Baudry, Devos, Rolland (Paris, Lille)
Analyses génétiques
- Gene hunting in Amytrophic lateral sclerosis/ PIs: Salachas/ Millecamps (Paris)
- Biomarkers in healthy carriers from familial ALS/ PI: Camu (Montpellier)
- Occurrence of TTRE mutation in a prospective cohort of suspected ALS patients/ PI: Soriani (Nice)
- SNP-ALS/ PIs: Dupuis/ Huin/ Blum/ Rolland/ Devos (Strasbourg/ Lille)
- Unravelling the genetic contribution to prognosis and endophenotypes in ALS using an extended cohort of patients (PULSE WGS)/ PI Dupuis (Strasbourg) Imaging topic (4)
- Radiological factors predicting the evolution of ALS/ PIs: Devos/ Lopes/ Viard/ Kuchcinski (Lille)
- Magnetic resonance imaging texture as a biomarker to predict the evolution of ALS/ PIs: Devos/ Betrouni (Lille)
Neuropsychologie
- Validation of the French version of the ECAS/ PIs: Lacomblez/ Glachant (Paris)
Projets finalisés
Projet “Cervical spinal cord MRI as possible biomarker in ALS” PI: Pradat (Paris) :
Article publié dans “Journal of Neurology, Neurosurgery and Psychiatry”: Comparison of spinal magnetic resonance imaging and classical clinical factors in predicting motor capacity in amyotrophic lateral sclerosis, 2023 – retrouvez l’article scientifique ici
Article publié dans “Journal of Neurology”: Quantitative brainstem and spinal MRI in ALS: implications for predicting non-invasive ventilation needs, 2024 – retrouvez l’article scientifique ici
Projet “Motor unit number index (MUNIX): an electrophysiologic technique to monitor disease progression in ALS” PIs: Attarian/ Grapperon (Marseille)
Article publié dans “Clinical Neurophysiology“: Assessment of the upper motor neuron in ALS using triple stimulation technique: a multicenter prospective study”, 2021 – retrouvez l’article scientifique ici
Article publié dans “Clinical Neurophysiology“: Could the motor unit number index be an early prognostic biomarker for amyotrophic lateral sclerosis?, 2024 – retrouvez l’article scientifique ici
Projet “Vesicles in the transmission of ALS (ViTAL)” PIs: Pradat/ Duguez (Paris)